Artavanis-Tsakonas Lab

An up-to-date list can be found on pubmed

Ubiquitin-Dependent Modification of Skeletal Muscle by the Parasitic Nematode, Trichinella spiralis. White RR, Ponsford AH, Weekes MP, Rodrigues RB, Ascher DB, Mol M, Selkirk ME, Gygi SP, Sanderson CM, Artavanis-Tsakonas K. PLoS Pathog. 2016 Nov 21;12(11):e1005977. doi: 10.1371/journal.ppat.1005977. eCollection 2016 Nov. PMID: 27870901

Stabilization of an unusual salt bridge in ubiquitin by the extra C-terminal domain of the proteasome-associated deubiquitinase UCH37 as a mechanism of its exo specificity.
Morrow ME, Kim MI, Ronau JA, Sheedlo MJ, White RR, Chaney J, Paul LN, Lill MA, Artavanis-Tsakonas K, Das C.
Biochemistry. 2013 Apr 25.

How helminths use excretory secretory fractions to modulate dendritic cells.
White RR, Artavanis-Tsakonas K.
Virulence. 2012 Nov 15;3(7).

Characterisation of the Trichinella spiralis deubiquitinating enzyme, TsUCH37, an evolutionarily conserved proteasome interaction partner.
White RR, Miyata S, Papa E, Spooner E, Gounaris K, Selkirk ME, Artavanis-Tsakonas K.
PLoS Negl Trop Dis. 2011 Oct;5(10):e1340.

The tetraspanin CD82 is specifically recruited to fungal and bacterial phagosomes prior to acidification.
Artavanis-Tsakonas K, Kasperkovitz PV, Papa E, Cardenas ML, Khan NS, Van der Veen AG, Ploegh HL, Vyas JM.
Infect Immun. 2011 Mar;79(3):1098-106.

Structural studies and characterization of the Plasmodium falciparum ubiquitin and Nedd8 hydrolase UCHL3.
Artavanis-Tsakonas K, Weihofen WA, Antos JM, Coleman BI, Comeaux CA, Duraisingh MT, Gaudet R, Ploegh HL.
J Biol Chem. 2010, Feb 26;285(9):6857-66.

Substrate filtering by the active site crossover loop in UCHL3 revealed by sortagging and gain-of-function mutations.
Popp MW, Artavanis-Tsakonas K, Ploegh HL.
J Biol Chem. 2009, Feb 6;284(6):3593-602.

Differential effects of Usp14 and Uch-L1 on the ubiquitin proteasome system and synaptic activity.
Walters BJ, Campbell SL, Chen PC, Taylor AP, Schroeder DG, Dobrunz LE, Artavanis-Tsakonas K, Ploegh HL, Wilson JA, Cox GA, Wilson SM.
Mol Cell Neurosci. 2008 Dec;39(4): 539-48.

Tubulation of Class II MHC compartments is microtubule-dependent and involves multiple endolysosomal membrane proteins in primary dendritic cells.
Vyas JM, Kim Y, Artavanis-Tsakonas K, van der Veen A., Love JC, Ploegh HL.
J Immunol. 2007, 178(11):7199-210.

Apicomplexan UCH-L3 retains dual specificity for ubiquitin and Nedd8 throughout evolution.
Frickel EM, Quesada V, Muething L, Gubbels MJ, Spooner E, Ploegh H, Artavanis-Tsakonas K.
Cell Microbiol. 2007, 9(6):1601-10.

Recruitment of CD63 to Cryptococcus neoformans phagosomes requires acidification.
Artavanis-Tsakonas K, Love JC, Ploegh HL and Vyas JM.
Proc Natl Acad Sci. 2006, 103(43):15945-50.

Identification by functional proteomics of a deubiquitinating/deNeddylating enzyme in Plasmodium falciparum.
Artavanis-Tsakonas K, Misaghi S, Comeaux CA, Catic A, Spooner E, Duraisingh MT, Ploegh HL.
Mol Microbiol. 2006, 61(5):1187-95.

Uninfected erythrocytes inhibit P. falciparum-induced cellular immune responses in whole blood assays.
Struik SS, Omer FM, Artavanis-Tsakonas K and Riley EM.
Blood. 2004, 103(8):3084-92.

Activation of a subset of human NK cells upon contact with Plasmodium falciparum-infected erythrocytes.
Artavanis-Tsakonas K, Eleme K, Davis DM and Riley EM.
J Immunol. 2003, 171(10):5396-405.

The war between the malaria parasite and the immune system: immunity, immunoregulation and immunopathology.
Artavanis-Tsakonas K, Tongren JE and Riley EM.
Clin Exp Immunol, 2003, 133(2):145-52.

Innate immune responses to Plasmodium falciparum malaria: early IFN-γ production is derived from NK cells and is preferentially induced by live rather than dead parasites.
Artavanis-Tsakonas K and Riley EM.
J Immunol, 2002, 169: 2956-2963.