As a class of pathogens parasites tend to establish chronic infections. This means that they have adapted intricate mechanisms of avoiding host immune responses, limiting tissue damage, and modulating their immediate surrounding to support their presence. By understanding how they adapt themselves to their environment, we stand to learn important information about host tissues they colonize. We have a particular interest in how parasites interfere with and manipulate the host ubiquitin-proteasome system. We currently focus on two organisms: the malaria parasite, Plasmodium falciparum, and the nematode Trichinella spiralis.